Meticulously maintained inside and out, the Mayo-Keene House

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Home For Sale

480 Dyer Prince Road

Eastham, Massachusetts 02642

Barnstable County

Waterfront: Yes

Water View: Yes

Community: 

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$3,599,000 3 br, 0.0 bath 4073 sq. ft. 0.960 acres

Meticulously maintained inside and out, the Mayo-Keene House (circa 1834) has been lovingly preserved while thoughtfully expanded & updated with every modern feature. Offering over 4,000 square feet of finished living space, this expansive 3-bedroom, 5.5-bath residence seamlessly blends historic character with today's quality craftsmanship. Inside, generous living areas allow everyone to enjoy their own space and privacy. A chef's kitchen featuring a Wolf gas range, dual Wolf ovens, two islands, built-in beverage refrigerator drawers, and custom cabinetry-perfect for cooking and entertaining alike. Enjoy radiant floor heating in all five bathrooms and the inviting four-season sunroom, where you can take in tranquil views of Rock Harbor and Rock Harbor Creek. Just a short stroll out of the driveway brings you to Dyer Prince Beach, where you can experience the beauty of Cape Cod Bay, or launch your boat nearby at the Eastham side of Rock Harbor. Whether enjoyed year-round, as a summer retreat, or a holiday gathering, this timeless home is truly turn-key - offering classic Cape Cod charm with all the ease of modern living. Seller welcomes offers with requests for buyer concessions

Interior:
  • Bedrooms: 3
  • Baths: 0.0
  • Sq Ft: 4073
  • Year Built: 1800
  • Utilities: 
  • Fireplaces: Has Fireplace
  • Stories: 2
  • Heat/AC: Oil, Propane (Heating)
  • Garage: Driveway, Open
Exterior:
  • Lot Size: 0.960 acre
  • Lot Dimensions: 
  • Waterfront: Yes
  • View Types: Harbor
  • Yard: 
  • Siding: Clapboard, Shingle Siding
  • Roof: Wood
  • Property Taxes: $20,829
  • MLS #: 22505232
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Contact Information:
Beach Home For Sale in Eastham, Massachusetts
Listing Agent: Alberti Team, Gibson Sotheby's International Realty, 508-237-2771, 508-255-6000 Listing Site, Listing Status: Active
Copyright © 2025 Cape Cod & Islands Association of REALTORS®, Inc.. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.
Ad Number: 6725582
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Updated: Oct 17, 2025

This property is a Home located at 480 Dyer Prince Road, Eastham, Massachusetts 02642, and is currently For Sale at $3,599,000. This Home has 3 bedrooms, 0.0 baths, 4073 sq ft.