This is an exceptionally rare chance to secure a versatile mixed

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Commercial For Sale

105 Palm Avenue

Upper Matecumbe Key, Florida 33036

Monroe County Water View: Yes

Community: Grove Park (815)

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$4,600,000 1 br, 4.0 bath 0 sq. ft. 0.000 acres

This is an exceptionally rare chance to secure a versatile mixed use commercial property in Islamorada's most established business corridors. Sale does not include real estate business. These three building and the land are ideally positioned for a wide range of commercial uses. Its central location within the Village of Islamorada provides strong access to both local residents and year-round visitor activity, making it an appealing option for investors and owner-operators.The building features a practical, adaptable layout suitable for professional offices, medical or wellness services, boutique retail, administrative operations, or specialty businesses. Large front-facing windows bring in natural light and enhance street presence, creating an inviting entry point for customers and clients. The interior opens into a flexible main area that can function as a reception space, retail floor, open office environment, or showroom. The footprint also supports the creation of private offices, treatment rooms, or storage areas, allowing businesses to tailor the space to their operational needs.On-site parking adds significant value, providing convenient access for customers and employees--an important advantage in Islamorada's commercial zones. Excellent signage opportunities ensure strong brand exposure. Easy ingress and egress make the location suitable for both destination-based and walk-in business models. Surrounded by established businesses, restaurants, marinas, and residential neighborhoods, the property benefits from a diverse and active customer base. Islamorada's strong local economy and tourism-driven demand enhance the long-term appeal of this location. With limited standalone commercial inventory available in the Upper Keys, 81579 Old Highway offers a unique setting for multiple uses within walking distance to Cheeca Lodge, The Moorings, and Worl Wide Sportsman. Totally renovated in 2019. Virtual tour

Interior:
  • Bedrooms: 1
  • Baths: 4.0
  • Sq Ft: 0
  • Year Built: 1951
  • Utilities: 
  • Fireplaces: 
  • Stories: 1
  • Heat/AC: 
  • Garage: 
Exterior:
  • Lot Size: 0.000 acre
  • Lot Dimensions: 
  • View Types: Water
  • Yard: 
  • Siding: 
  • Roof: 
  • Property Taxes: $17,206
  • MLS #: 618814
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Contact Information:
Beach Commercial For Sale in Upper Matecumbe Key, Florida
Listing Agent: Judy Rossignol, Realty ONE Group Engage the Keys, 305-393-0523, 305-393-0523 Listing Site, Listing Status: Active
Copyright © 2026 Florida Keys Board of REALTORS®. All rights reserved. All information provided by the listing agent/broker is deemed reliable but is not guaranteed and should be independently verified.
Ad Number: 7320362
Viewed 22 times.
Updated: Feb 25, 2026

This property is a Commercial located at 105 Palm Avenue, Upper Matecumbe Key, Florida 33036, and is currently For Sale at $4,600,000. This Commercial has 1 bedrooms, 4.0 baths, 0 sq ft.